Russell-Silver syndrome is a disorder present at birth involving poor growth. One side of the body also will appear to be larger than the other.
Silver-Russell syndrome; Silver syndrome
Causes, incidence, and risk factors
Up to 1 in 10 children with this syndrome have a problem involving chromosome 7. In other patients, the syndrome may affect chromosome 11.
Most of the time, it occurs in people with no family history of the disease.
The estimated number of people who develop this condition varies greatly. Some say it affects about 1 in 3,000 people. Other reports say it affects 1 in 100,000 people. Males and females are equally affected.
Symptoms can include:
Birthmarks that are the color of coffee with milk (cafe-au-lait marks)
Many specialists may be involved in treating this condition:
A doctor specializing in genetics can help diagnose Russell-Silver syndrome.
A gastroenterologist or nutritionist can help develop the proper diet to enhance growth.
An endocrinologist may prescribe growth hormone, if it is needed.
Genetic counselors and psychologists may also be involved.
Older children and adults do not show typical features as clearly as infants or younger children. Intelligence may be normal, although the patient may have a learning disability.
Chewing or speaking difficulty if jaw is very small
Calling your health care provider
Call your health care child's provider if signs of Russell-Silver syndrome develop. Make sure your child's height and weight is measure during each well child visit. The doctor may refer you to:
A genetic professional for a full evaluation and chromosome studies
A pediatric endocrinologist for management of your child's growth problems
Chad Haldeman-Englert, MD, FACMG, Wake Forest School of Medicine, Department of Pediatrics, Section on Medical Genetics, Winston-Salem, NC. Review provided by VeriMed Healthcare Network. Also reviewed by A.D.A.M. Health Solutions, Ebix, Inc., Editorial Team: David Zieve, MD, MHA, David R. Eltz, and Stephanie Slon.